Publications
Parra-Guillen ZP, Sancho-Araiz A, Mayawala K, Zalba S, Garrido MJ, de Alwis D, Troconiz IF, Freshwater T. Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically-Based Modeling. Clin Pharmacol Ther. 2023 Sep;114(3):623-632. doi: 10.1002/cpt.2937. Epub 2023 Jun 2. PMID: 37170933.
Peribañez-Dominguez, S., & Parra-Guillen, Z. P. A physiologically based pharmacokinetic model for V937 oncolytic virus in mice. Frontiers in Pharmacology (September 2023), 1–11. https://doi.org/10.3389/fphar.2023.1211452
Riva, Natalia; Galván, Eugenia; Pérez, Erika; Cáceres Guido, Paulo; Clarisa Lopez, Licciardone, Nieves; Buamscha, Daniel; Ibarra, Manuel; Troconiz de Fernandez, Inaki; Schaiquevich, Paula. Population pharmacokinetic model of sublingual tacrolimus administrations in pediatric liver transplant patients. Br J Clin Pharmacol. 2023 Mar;89(3):1115-1126. Available at https://pubmed.ncbi.nlm.nih.gov/36222177/
Zalba S, Ten Hagen TLM, Burgui C, Garrido MJ. Stealth nanoparticles in oncology: Facing the PEG dilemma. J Control Release. 2022 Nov;351:22-36. doi: 10.1016/j.jconrel.2022.09.002. Epub 2022 Sep 19. PMID: 36087801 Review.
Tamariz-Amador L.E, Rodríguez-Otero P, Jiménez de Ubieto A, Rosiñol L, Oriol A, Rios R, Sureda A, Blanchard M.J, Hernández Miguel T, Cabañas Perianes V, Jarque I, Bargay J, Gironella M, De Arriba F, Palomera L, Gonzalez-Montes Y, Martí JM, Krsnik I, Arguiñano J.M, González M.E, Casado L.F, González-Rodriguez A.P, López-Anglada L, Puig N, Cedena MT, Paiva B, Mateos M.V, San- Miguel J, Lahuerta J.J, Bladé J, Trocóniz I.F. Prognostic value of serum paraprotein response kinetics in patients with newly diagnosed multiple mieloma. Clinical lymphoma, mieloma and leukemia. May 04, 2022 DOI:https://doi.org/10.1016/j.clml.2022.04.024.
Laura Butragueño-Laiseca, Nicolás Marco-Ariño, Iñaki F Troconiz, Santiago Grau, Nuria Campillo, Xandra García, Belén Padilla, Sarah Nicole Fernández, María Slöcker, María José Santiago. Population pharmacokinetics of piperacillin in critically ill children including those undergoing continuous kidney replacement therapy. Clin Microbiol Infect. 2022 Apr 4:S1198-743X(22)00170-7. doi: 10.1016/j.cmi.2022.03.031. Online ahead of print.
Marco-Ariño N, Vide S, Agustí M, Chen A, Jaramillo S, Irurzun-Arana I, Pacheco A, Gonzalez C, Jensen EW, Capsi-Morales P, Valencia JF, Troconiz IF, Gambus PL, Larson MD. Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids. CPT Pharmacometrics Syst Pharmacol. 2022 May;11(5):581-593.
Mafalda Couto, Sérgio Vide, Nicolás Marco-Ariño, Iñaki F Troconiz, Simão Esteves, Catarina S Nunes, Pedro Amorim, Joaquim Mendes. Comparison of two pharmacokinetic-pharmacodynamic models of rocuronium bromide during profound neuromuscular block: analysis of estimated and measured post-tetanic count effect. Br J Anaesth. 2022 Mar;128(3):473-481.
Navarro-Ocón A, Blaya-Cánovas JL, López-Tejada A, Blancas I, Sánchez-Martín RM, Garrido MJ, Griñán-Lisón C, Calahorra J, Cara FE, Ruiz-Cabello F, Marchal JA, Aptsiauri N, Granados-Principal S. Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer. Pharmaceutics. 2022 Feb 25;14(3):505.
Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD. IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET). Trials. 2022 Feb 19;23(1):163.
Vera-Yunca D, Córdoba KM, Parra-Guillen ZP, Jericó D, Fontanellas A, Trocóniz IF. Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria. Br J Pharmacol. 2022 Feb 15. doi: 10.1111/bph.15821. Online ahead of print.
Córdoba KM, Serrano-Mendioroz I, Jericó D, Merino M, Jiang L, Sampedro A, Alegre M, Corrales F, Garrido MJ, Martini PGV, Lanciego JL, Prieto J, Berraondo P, Fontanellas A. Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria. Sci Transl Med. 2022 Jan 12;14(627):eabc0700.
Ameijeiras Rodríguez, C.; Henriques, S.C.; Sancho-Araiz, A.; Trocóniz, I.F.; Almeida, L.; Silva, N.E. Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis. Pharm. Res. 2021, 38, 2047–2063.
Sancho Araiz A; Zalba S; Garrido MJ, Berraondo P; Top B; de Alwis D; Parra-Guillén ZP; Mangas-San Juan V; Trocóniz IF. Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors. Cancers (Basel). 2021 Oct 9;13(20):5049.
Eduardo Asín-Prieto, Zinnia P Parra-Guillen, José David Gómez Mantilla, Joris Vandenbossche, Kim Stuyckens, Xavier Woot de Trixhe, Juan José Perez-Ruixo, Iñaki F Troconiz. A quantitative systems pharmacology model for acute viral hepatitis B. Comput Struct Biotechnol J. 2021 Sep 2;19:4997-5007.
Parra-Guillén ZP; Freshwater T; Cao, Mayawala, Zalba S; Garrido MJ; de Alwis D; Trocóniz IF. Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration. Front Pharmacol. 2021 Jul 23;12:705443.
ten Hagen TLM; Dreher MR; Seynhaeve ALB; Zalba S; Amin M; Li L; Haemmerich D. Drug Transport Kinetics of Intravascular Triggered Drug Delivery Systems. Commun Biol. 2021 Jul 28;4(1):920.
Zinnia P Parra-Guillen, Tomoko Freshwater, Youfang Cao, Kapil Mayawala , Sara Zalba, Maria J Garrido, Dinesh de Alwis, Iñaki F Troconiz. Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration. Front Pharmacol. 2021 Jul 23;12:705443.
Sancho-Araiz, A.; Mangas-Sanjuan, V.; Trocóniz, I.F. The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives. Pharmaceutics. 2021, Vol. 13, Page 1016 2021, 13, 1016.
André Mouraux, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C Chapman, Giulia Di Stefano, Nanna Brix Finnerup, Luis Garcia-Larrea, Marcus Goetz, Anna Kostenko, Bernhard Pelz, Esther Pogatzki-Zahn, Karin Schubart, Alexandre Stouffs, Andrea Truini , Irene Tracey, Iñaki F Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer , Keith G Phillips, Rolf-Detlef Treede. IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG). Trials. 2021 Jun 17;22(1):404.
Diego Vera-Yunca, Zinnia P Parra-Guillen, Pascal Girard, Iñaki F Trocóniz, Nadia Terranova. Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer. Br J Clin Pharmacol. 2022 Jan;88(1):166-177.
Merino M; Lozano T; Casares N; Lana H; Troconiz IF; ten Hagen TLM; Kochan G;Berraondo P; Zalba S; Garrido MJ. Dual activity of PD‑L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model. J Nanobiotechnology. 2021 Apr 13;19(1):102.
Manuel Ibarra, Iñaki F Trocóniz, Pietro Fagiolino. Enteric reabsorption processes and their impact on drug pharmacokinetics. Sci Rep. 2021 Mar 11;11(1):5794.
Zalba S; Belsue V; Topp B; de Alwis D; Álvarez M; Trocóniz IF; Berraondo P; Garrido MJ. Modulation of intratumoral myeloid cells is a hallmark of the anti-tumor efficacy of α-PD-1-based combinations. Br J Cancer. 2021 Mar;124(7):1275-1285.
Butragueño-Laiseca L, Troconiz IF, Grau S, Campillo N, García X, Padilla B, Fernández SN, Santiago MJ. Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury. Antibiotics (Basel). 2020 Dec 10;9(12):887.
Michelet R, Melin J, Parra-Guillen ZP, Neumann U, Whitaker MJ, Stachanow V, Huisinga W, Porter J, Blankenstein O, Ross RJ, Kloft C. Response to 'Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia. Eur J Endocrinol. 2020 Dec;183(6):L29-L30.
Irurzun-Arana I, Rackauckas C, McDonald TO, Troconiz IF. Beyond deterministic models in drug discovery and development. Trends in Pharmacological Sciences. Sep 2020 [In Press].
Michelet R, Melin J, Parra-Guillen ZP, Neumann U, Whitaker JM, Stachanow V, Huisinga W, Porter J, Blankenstein O, Ross RJ, Kloft C. Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children. Eur J Endocrinol. 2020 Oct;183(4):357-368.
Carreño F, Helfer VE, Staudt KJ, Olivo LB, Paese K, Meyer FS, Herrmann AP, Guterres SS, Kuze Rates SM, Trocóniz I, Dalla Costa T. Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia. J Pharmacol Exp Ther. 2020 Oct;375(1):49-58.
Zalba S , Seynhaeve ALB , Brouwers JF , Süss R , Verheij M , Ten Hagen TLM. Sensitization of drug resistant sarcoma tumors by membrane modulation via short chain sphingolipid-containing nanoparticles. Nanoscale. 2020 Aug 28;12(32):16967-16979.
Irurzun-Arana I, McDonald TO, Trocóniz IF, Michor F. Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance. Cancer Res. 2020 Aug 15;80(16):3372-3382.
Parra-Guillen ZP, Fontanellas A, Jiang L, Jericó D, Martini P, Vera-Yunca D, Hard M, Guey LT, Troconiz IF. Disease pharmacokinetic-
Zalba S, Contreras-Sandoval AM, Martisova E, Debets R, Smerdou C, Garrido MJ. Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs. Pharmaceutics. 2020 Jun 26;12(6):595.
Irurzun-Arana I, Asín-Prieto E, Martín-Algarra S, Trocóniz IF. Predicting circulating biomarker response and its impact on the survival of advanced melanoma patients treated with adjuvant therapy. Sci Rep. 2020 May 4;10(1):7478.
Garcia-Cremades M, Melillo N, Troconiz IF, Magni P. Mechanistic Multiscale Pharmacokinetic Model for the Anticancer Drug 2',2'-difluorodeoxycytidine (Gemcitabine) in Pancreatic Cancer. Clin Transl Sci. 2020 May;13(3):608-617.
Balbas-Martinez V, Asin-Prieto E, Parra-Guillen ZP, Troconiz IF. A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease. J Pharmacol Exp Ther. 2020 Mar;372(3):299-307.
Parra-Guillen ZP, Schmid U, Janda A, Freiwald M, Troconiz IF. Model-informed dose selection for Xentuzumab, a dual insulin-like growth factor-I/II -neutralizing antibody. Clin Pharmacol Ther. 2020 Mar;107(3):597-606.
Solans BP, Garrido MJ, Trocóniz IF. Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology. Clin Pharmacokinet. 2020 Feb;59(2):123-135.
Vera-Yunca D, Girard P, Parra-Guillen ZP, Munafo A, Troconiz IF, Terranova N. Machine learning analysis of individual tumor lesions in four metastatic colorectal cancer clinical studies: linking tumor heterogeneity to overall survival. AAPS. 2020 Mar 16;22(3):58.
Melin J, Parra-Guillen ZP, Michelet R, Truong T, Huisinga W, Hartung N, Hindmarsh P, Kloft C. Pharmacokinetic/
Solans BP, Chiesa R, Doncheva B, Prunty H, Veys P, Troconiz IF, Standing JF. Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning. Br J Clin Pharmacol. 2020 Feb 19;86(8):1537-1549
Cattrall JWS, Asín-Prieto E, Freeman J, Trocóniz IF, Kirby A. A pharmacokinetic-
Asín-Prieto E, Parra-Guillen ZP, Mantilla JDG, Vandenbossche J, Stuyckens K, de Trixhe XW, Perez-Ruixo JJ, Troconiz IF. Immune network for viral hepatitis B: Topological representation. Eur J Pharm Sci. 2019 Aug 1;136:104939. doi: 10.1016/j.ejps.2019.05.017.
Martin-Romano P, Solans BP, Cano D, Subtil JC, Chopitea A, Arbea L, Lozano MD, Castanon E, Baraibar I, Salas D, Hernandez-Lizoain JL, Trocóniz IF, Rodriguez J. Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling.PLoS One. 2019 May 9;14(5):e0215970. doi: 10.1371/journal.pone.0215970. eCollection 2019.
Solans BP, López-Díaz de Cerio A, Elizalde A, Pina LJ, Inogés S, Espinós J, Salgado E, Mejías LD, Trocóniz IF, Santisteban M. Assessing the impact of the addition of dendritic cell vaccination to neoadjuvant chemotherapy in breast cancer patients: A model-based characterization approach. Br J Clin Pharmacol. 2019 Aug;85(8):1670-1683.
Melin J, Hartung N, Parra-Guillen ZP, Whitaker MJ, Ross RJ, Kloft C. The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing. ClinEndocrinol (Oxf). 2019 Jul;91(1):33-40. doi: 10.1111/cen.13969.
Centanni M, Moes DJAR, Trocóniz IF, Ciccolini J, van Hasselt JGC. Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors. ClinPharmacokinet. 2019 Jul;58(7):835-857. doi: 10.1007/s40262-019-00748-2. Review.
Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF. Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies. AAPS J. 2019 Jan 31;21(2):23. doi: 10.1208/s12248-018-0291-9.
Ibarra M, Dalla Costa T, Schaiquevich P, Cristofoletti R, Hernández González I, Fajardo-Robledo NS, Aragón Novoa M, Pecchio M, Cortinez I, Trocóniz IF, Romero-Tejeda EM. Iberoamerican Pharmacometrics Network Congress 2018 Report: Fostering Modeling and Simulation Approaches for Drug Development and Regulatory and Clinical Applications in Latin America.CPT Pharmacometrics Syst Pharmacol. 2019 Apr;8(4):197-200. doi: 10.1002/psp4.12387.
Merino M, Contreras A, Casares N, Troconiz IF, Ten Hagen TL, Berraondo P, Zalba S, Garrido MJ. A new immune-nanoplatform for promoting adaptive antitumor immune response. Nanomedicine. 2019 Apr;17:13-25. doi: 10.1016/j.nano.2018.12.016.
Saeed M, Zalba S, Seynhaeve ALB, Debets R, Ten Hagen TLM. Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response. Int J Nanomedicine. 2019 Mar 26;14:2069-2089. doi: 10.2147/IJN.S190736. eCollection 2019.
Vera-Yunca D, Serrano-Mendioroz I, Sampedro A, Jericó D, Trocóniz IF, Fontanellas A, Parra-Guillén ZP. Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. Mol Genet Metab. 2019 Nov ; 128(3):367-375. doi: 10.1016/j.ymgme.2018.12.009.
Fernandez-Teruel C, Gonzalez I, Trocóniz IF, Lubomirov R, Soto A, Fudio S. Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer. ClinPharmacokinet. 2019 Mar;58(3):363-374. doi: 10.1007/s40262-018-0701-2.
Kirby A, Asín-Prieto E, Burns FA, Ewin D, Fatania K, Kailavasan M, Nisar S, Pericleous A, Trocóniz IF, Burke D. Colo-Pro: a pilot randomised controlled trial to compare standard bolus-dosed cefuroxime prophylaxis to bolus-continuous infusion-dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery. Eur J ClinMicrobiol Infect Dis. 2019 Feb;38(2):357-363. doi: 10.1007/s10096-018-3435-z.
Balbas-Martinez V, Michelet R, Edginton AN, Meesters K, Trocóniz IF, Vermeulen A. Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection. Eur J Pharm Sci. 2019 Feb 1;128:171-179. doi: 10.1016/j.ejps.2018.11.033.
Yoncheva K, Merino M, Shenol A, Daskalov NT, Petkov PS, Vayssilov GN, Garrido MJ. Optimization and in-vitro/in-vivo evaluation of doxorubicin-loaded chitosan-alginate nanoparticles using a melanoma mouse model. Int J Pharm. 2019 Feb 10;556:1-8. doi: 10.1016/j.ijpharm.2018.11.070
Martínez-Cuadrón D, Gil C, Serrano J, Rodríguez G, Pérez-Oteyza J, García-Boyero R, Jiménez-Bravo S, Vives S, Vidriales MB, Lavilla E, Pérez-Simón JA, Tormo M, Colorado M, Bergua J, López JA, Herrera P, Hernández-Campo P, Gorrochategui J, Primo D, Rojas JL, Villoria J, Moscardó F, Troconiz I, Linares Gómez M, Martínez-López J, Ballesteros J, Sanz M, Montesinos P; Spanish PETHEMA group. A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients. Leuk Res. 2019 Jan;76:1-10. doi: 10.1016/j.leukres.2018.11.006.
Hernando B, Martinez-Simon A, Cacho-Asenjo E, Troconiz IF, Honorato-Cia C, Panadero A, Naval LL, Nuñez-Cordoba JM. Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study. Clin Oral Investig. 2019 Jan;23(1):391-397. doi: 10.1007/s00784-018-2447-5.
Smith MK, Moodie SL, Bizzotto R, Blaudez E, Borella E, Carrara L, Chan P, Chenel M, Comets E, Gieschke R, Harling K, Harnisch L, Hartung N, Hooker AC, Karlsson MO, Kaye R, Kloft C, Kokash N, Lavielle M, Lestini G, Magni P, Mari A, Mentré F, Muselle C, Nordgren R, Nyberg HB, Parra-Guillén ZP, Pasotti L, Rode-Kristensen N, Sardu ML, Smith GR, Swat MJ, Terranova N, Yngman G, Yvon F, Holford N; DDMo Reconsortium. Model Description Language (MDL): A Standard for Modeling and Simulation CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):647-650. doi: 10.1002/psp4.12222.
Henrich A, Joerger M, Kraff S, Jaehde U, Huisinga W, Kloft C, Parra-Guillen ZP. Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia. J Pharmacol Exp Ther. 2017 Aug;362(2):347-358. doi: 10.1124/jpet.117.240309
Reynaldo-Fernández G, Solozábal J, Amaro D, Fernández-Sánchez EM, Rodríguez-Vera L, Bermejo M, Mangas-Sanjuan V, Troconiz IF. Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylatedrHuEPO and ior®EPOCIM in New Zealand rabbits.Eur J Pharm Sci. 2018 Jul 30;120:123-132. doi: 10.1016/j.ejps.2018.04.047
Parra-Guillen ZP, Mangas-Sanjuan V, Garcia-Cremades M, Troconiz IF, Mo G, Pitou C, Iversen PW, Wallin JE. Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts. J PharmacolExpTher. 2018 Jul;366(1):96-104. doi: 10.1124/jpet.118.248286.
Ruiz-Cerdá L, Asín-Prieto E, Parra-Guillen ZP, Trocóniz IF. The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing. Clin Cancer Res. 2018 Jul 15;24(14):3236-3238. doi: 10.1158/1078-0432.CCR-18-0580
Parra-Guillen ZP, Mangas-Sanjuan V, Garcia-Cremades M, Troconiz IF, Mo G, Pitou C, Iversen PW, Wallin JE. Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts. J PharmacolExpTher. 2018 Jul;366(1):96-104. doi: 10.1124/jpet.118.248286. Epub 2018 Apr 24. PMID: 29691287
Mangas-Sanjuan V, Navarro-Fontestad C, García-Arieta A, Trocóniz IF, Bermejo M. Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter. Eur J Pharm Sci. 2018 May 30;117:193-203. doi: 10.1016/j.ejps.2018.02.014.
Irurzun-Arana I, Janda A, Ardanza-Trevijano S, Trocóniz IF. Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer. PLoSComput Biol. 2018 Apr 19;14(4):e1006087. doi: 10.1371/journal.pcbi.1006087.
Melin J, Parra-Guillen ZP, Hartung N, Huisinga W, Ross RJ, Whitaker MJ, Kloft C. Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults. ClinPharmacokinet. 2018 Apr;57(4):515-527. doi: 10.1007/s40262-017-0575-8.
Merino M, Zalba S, Garrido MJ. Immunoliposomes in clinical oncology: State of the art and future perspectives. J Control Release. 2018 Apr 10;275:162-176. doi: 10.1016/j.jconrel.2018.02.015
Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF. Predicting tumour growth and its impact on survival in gemcitabine-treated patients with advanced pancreatic cancer. Eur J Pharm Sci. 2018 Mar 30;115:296-303. doi: 10.1016/j.ejps.2018.01.033.
Balbas-Martinez V, Ruiz-Cerdá L, Irurzun-Arana I, González-García I, Vermeulen A, Gómez-Mantilla JD, Trocóniz IF. A systems pharmacology model for inflammatory bowel disease. PLoS One. 2018 Mar 7;13(3):e0192949. doi: 10.1371/journal.pone.0192949.
P Solans B, Fleury A, Freiwald M, Fritsch H, Haug K, Trocóniz IF. Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine. ClinPharmacokinet. 2018 Mar;57(3):379-392. doi: 10.1007/s40262-017-0566-9.
A. Soraluce, E. Asín-Prieto, A. Rodríguez-Gascón, H. Barrasa, J. Maynar, E. Carcelero, D. Soy, A. Isla. Population pharmacokinetics of amikacin in critically ill patients. Antimicrob Agents Chemother. March 11 2018
Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP. Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative.CPT PharmacometricsSystPharmacol. 2018 Feb;7(2):65-68. doi: 10.1002/psp4.12262.
Klopp-Schulze L, Joerger M, Wicha SG, Ter Heine R, Csajka C, Parra-Guillen ZP, Kloft C. Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients. Clin Pharmacokinet. 2018 Feb;57(2):229-242. doi: 10.1007/s40262-017-0555-z.
Malinovskaja-Gomez K, Espuelas S, Garrido MJ, Hirvonen J, Laaksonen T. Comparison of liposomal drug formulations for transdermal iontophoretic drug delivery. Eur J Pharm Sci. 106: 294-301 (2017).
Martinez-Simon A, Alegre M, Honorato-Cia C, Nuñez-Cordoba JM, Cacho-Asenjo E, Trocóniz IF, Carmona-Abellán M, Valencia M, Guridi J. Effect of Dexmedetomidine and Propofol on Basal Ganglia Activity in Parkinson Disease: A Controlled Clinical Trial. Anesthesiology 126(6):1033-1042 (2017).
Parra-Guillen ZP, Berger PB, Haschke M, Donzelli M, et. al. Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) Receiving Erlotinib Treatment. Basic Clin Pharmacol Toxicol. (2017). doi: 10.1111/bcpt.12801.
Garrido MJ, Berraondo P, Trocóniz IF. Commentary on Pharmacometrics for Immunotherapy. CPT Pharmacometrics Syst Pharmacol. Jan; 6(1):8-10 (2017) . Erratum in: CPT Pharmacometrics Syst Pharmacol. ;6(4):277 (2017).
Irurzun-Arana I, Pastor JM, Trocóniz IF, Gómez-Mantilla JD. Advanced Boolean modeling of biological networks applied to systems pharmacology. Bioinformatics. 33 (7): 1040-1048 (2017).
Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF. "Characterising Gemcitabine effects administered as single agent or combined with carboplatin in mice pancreatic and ovarian cancer xenografts. A semi-mechanistic pharmacokinetic/pharmacodynamics tumour growth-response model.t” J Pharmacol Exp Ther. 360 (3): 445-456 (2017).
Pérez-Castelló I, Mangas-Sanjuan V, González-García I, Gonzalez-Alvarez I, Bermejo M, Marco-Garbayo JL, Trocóniz IF "Population pharmacokinetic model of lithium and drug compliance assessment” Eur europsychopharmacol 26(12):1868-1876 (2016)
Contreras A, Merino M, Vasquez M, Troconiz IF, Berraondo P, Garrido M. Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model. Oncotarget 22;7(47):76891-76901 (2016).
Ouerdani A, Goutagny S, Kalamarides M, Troconiz IF, Benjamin Ribba. Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2. Cancer Chemother Pharmacol 77: 1263-1273 (2016).
Ruiz-Cerdá ML, Irurzun-Arana I, González-Garcia I, Hu C, Zhou H, Vermeulen A, Trocóniz IF, Gómez-Mantilla JD. Towards patient stratification and treatment in the autoimmune disease lupus erythematosus using a systems pharmacology approach. Eur J Pharm Sci. 30;94:46-58 (2016)
Mangas-Sanjuan V, Pastor JM, Rengelshausen J, Bursi R, Troconiz IF. Population PK/PD modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects. Br J Clin Pharmacol. 82:92-107 (2016).
Buil-Bruna N, Dehez M, Manon A, Nguyen TX, Trocóniz IF. Establishing the quantitative relationship between Lanreotide Autogel®, Chromogranin A and progression free survival in patients with non-functioning gastroenteropancreatic neuroendocrine tumors. AAPS J. 18: 703-712 (2016).
Zalba S, Contreras AM, Merino M, Navarro I, de Ilarduya CT, Trocóniz IF, Koning G, Garrido MJ. EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model. Nanomedicine (Lond). 11: 465-477 (2016).
Buil-Bruna N, López-Picazo JM, Martín-Algarra S, Trocóniz IF. Bringing model-based prediction to oncology clinical practice: a review of pharmacometrics principles and applications. The Oncologist. 21: 220-232 (2016).
Hannam JA, Borrat X, Trocóniz IF, Valencia JF, Jensen EW, Pedroso A, Muñoz J, Castellví-Bel S, Castells A, Gambús PL. Modeling respiratory depression induced by remifentanil and propofol during sedation and analgesia using a continuous noninvasive measurement of pCO2. J Pharmacol Exp Ther. 356: 563-573 (2016).
Buil-Bruna N, Garrido MJ, Dehez M, Manon A, Nguyen TX, Gomez-Panzani EL, Trocóniz IF. Population pharmacokinetic analysis of Lanreotide Autogel®/Depot in the treatment of neuroendocrine tumors: pooled analysis of four clinical trials. Clin Pharmacokinet. 55: 461-473 (2016).
Swat MJ, Moodie S, Wimalaratne SM, Kristensen NR, Lavielle M, Mari A, Magni P, Smith MK, Bizzotto R, Pasotti L, Mezzalana E, Comets E, Sarr C, Terranova N, Blaudez E, Chan P, Chard J, Chatel K, Chenel M, Edwards D, Franklin C, Giorgino T, Glont M, Girard P, Grenon P, Harling K, Hooker AC, Kaye R, Keizer R, Kloft C, Kok JN, Kokash N, Laibe C, Laveille C, Lestini G, Mentré F, Munafo A, Nordgren R, Nyberg HB, Parra-Guillen ZP, Plan E, Ribba B, Smith G, Trocóniz IF, Yvon F, Milligan PA, Harnisch L, Karlsson M, Hermjakob H, Le Novère N. Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development. CPT Pharmacometrics Syst Pharmacol. 4: 316-319 (2015).
Zalba S, Contreras AM, Haeri A, Ten Hagen TL, Navarro I, Koning G, Garrido MJ. Cetuximab-oxaliplatin-liposomes for epidermal growth factor receptor targeted chemotherapy of colorectal cancer. J Control Release. 210: 26-38 (2015).
Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M. Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain Behav Immun. 50: 203-208 (2015).
Mangas-Sanjuan V, Buil-Bruna N, Garrido MJ, Soto E, Trocóniz IF. Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules. J Pharmacol Exp Ther. 354: 55-64 (2015).
Buil-Bruna N, Sahota T, López-Picazo JM, Moreno-Jiménez M, Martín-Algarra S, Ribba B, Trocóniz IF. Early prediction of disease progression in small cell lung cancer: toward model-based personalized medicine in oncology. Cancer Res. 75: 2416-2425 (2015).
Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M. Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid. Eur J Pharm Sci.74: 86-94 (2015).
Jacobo-Cabral CO, García-Roca P, Romero-Tejeda EM, Reyes H, Medeiros M, Castañeda-Hernández G, Trocóniz IF. Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation. Br J Clin Pharmacol. 80: 630-641 (2015).
Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M. Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients. Eur J Pharm Sci. 73:57-63 (2015).
Asín-Prieto E, Soraluce A, Trocóniz IF, Campo Cimarras E, Sáenz de Ugarte Sobrón J, Rodríguez-Gascón A, Isla A. Population pharmacokinetic models for cefuroxime and metronidazole used in combination as prophylactic agents in colorectal surgery: Model-based evaluation of standard dosing regimens. Int J Antimicrob Agents. 45: 504-511 (2015).
Venkatakrishnan K, Friberg L, Ouellet D, Mettetal J, Stein A, Trocóniz I, Bruno R, Mehrotra N, Gobburu J, Mould D. Optimizing oncology therapeutics through quantitative translational and clinical pharmacology: challenges and opportunities. Clin Pharmacol Ther. 97: 37-54 (2015).
Yuen ES, Trocóniz IF. Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans? Seizure. 24: 21-7 (2015).
Parra-Guillen ZP, Cendrós Carreras JM, Peraire C, Obach R, Prunynosa J, Chetaille E, Trocóniz IF. Population Pharmacokinetic Modelling of Irosustat in Postmenopausal Women with Oestrogen-Receptor Positive Breast Cancer Incorporating Non-Linear Red Blood Cell Uptake. Pharm Res. 32: 1493-1504 (2015).
Allegaert K, Holford N, Anderson BJ, Holford S, Stuber F, Rochette A, Trocóniz IF, Beier H, de Hoon JN, Pedersen RS, Stamer U. Tramadol and O-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study. Clin Pharmacokinet. 54: 167-178 (2015).
Gambús PL, Trocóniz IF. Pharmacokinetic-pharmacodynamic modelling in anesthesia. Br J Clin Pharmacol. 79: 72-84 (2015).
Borrat X, Valencia JF, Magrans R, Gimenez-Mila M, Mellado R, Sendino O, Perez M, Nunez M, Jospin M, Jensen EW, Troconiz I, Gambus PL. Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy. Anesth Analg. 121: 90-96 (2015).
Gómez-Mantilla JD, Trocóniz IF, Parra-Guillén Z, Garrido MJ. Review on modeling anti-antibody responses to monoclonal antibodies. J Pharmacokinet Pharmacodyn. 41: 523-36 (2014).
Buil-Bruna N, López-Picazo JM, Moreno-Jiménez M, Martín-Algarra S, Ribba B, Trocóniz IF. A population pharmacodynamic model for lactate dehydrogenase and neuron specific enolase to predict tumor progression in small cell lung cancer patients. AAPS J. 16: 609-19 (2014).
Bennett TA, Montesinos P, Moscardo F, Martinez-Cuadron D, Martinez J, Sierra J, García R, de Oteyza JP, Fernandez P, Serrano J, Fernandez A, Herrera P, Gonzalez A, Bethancourt C, Rodriguez-Macias G, Alonso A, Vera JA, Navas B, Lavilla E, Lopez JA, Jimenez S, Simiele A, Vidriales B, Gonzalez BJ, Burgaleta C, Hernandez Rivas JA, Mascuñano RC, Bautista G, Perez Simon JA, Fuente AD, Rayón C, Troconiz IF, Janda A, Bosanquet AG, Hernandez-Campo P, Primo D, Lopez R, Liebana B, Rojas JL, Gorrochategui J, Sanz MA, Ballesteros J. Pharmacological profiles of acute myeloid leukemia treatments in patient samples by automated flow cytometry: a bridge to individualized medicine. Clin Lymphoma Myeloma Leuk. 14: 305-318 (2014).
Taneja A, Troconiz IF, Danhof M, Della Pasqua O; Neuropathic pain project of the PKPD modelling platform. Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain. Pharm Res. 31:593-606 (2014).
Asín-Prieto E, Rodríguez-Gascón A, Trocóniz IF, Soraluce A, Maynar J, Sánchez-Izquierdo JÁ, Isla A. Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis. J Antimicrob Chemother. 69: 180-9 (2014).
Ribba B, Holford NH, Magni P, Trocóniz I, Gueorguieva I, Girard P, Sarr C, Elishmereni M, Kloft C, Friberg LE. A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis. CPT Pharmacometrics Syst Pharmacol. 3: e113 (2014).
Velez de Mendizabal N, Hutmacher MM, Troconiz IF, Goñi J, Villoslada P, Bagnato F, Bies RR. Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: a population approach. PLoS One. 8: e73361 (2013).
Parra-Guillen ZP, Berraondo P, Ribba B, Trocóniz IF. Modeling tumor response after combined administration of different immune-stimulatory agents. J Pharmacol Exp Ther. 346: 432-42 (2013).
Zalba S, Garrido MJ. Liposomes, a promising strategy for clinical application of platinum derivatives. Expert Opin Drug Deliv. 10: 829-844 (2013).
Parra-Guillen ZP, Berraondo P, Grenier E, Ribba B, Troconiz IF. Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies.. AAPS J. 15: 797-807 (2013).
Borrat X, Trocóniz IF, Valencia JF, Rivadulla S, Sendino O, Llach J, Muñoz J, Castellví-Bel S, Jospin M, Jensen EW, Castells A, Gambús PL. Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the synergistic relation between propofol and remifentanil: sedation and analgesia in endoscopic procedures. Anethesiology. 118:1395-407 (2013).
Vélez de Mendizábal N, Staab A, Schäfer HG, Trommeshauser D, Döge C, Klüglich M, Roberts J, Trocóniz IF. Joint population pharmacokinetic/pharmacodynamic model for the heart rate effects at rest and at the end of exercise of cilobradine. Pharm Res. 30:1110-22 (2013).
Parra-Guillen ZP, Janda A, Alzuguren P, Berraondo P, Hernandez-Alcoceba R, Troconiz IF. Target-mediated disposition model describing the dynamics of IL12 and IFNγ after administration of a mifepristone-inducible adenoviral vector for IL-12 expression in mice. AAPS J. 15:183-94 (2013).
Parra-Guillen ZP, Fioravanti J, Medina-Echeverz J, Gomar C, Ardaiz N, Troconiz IF, Berraondo P. Kinetic and dynamic computational model-based characterization of new proteins in mice: application to interferon alpha linked to apolipoprotein A-I. PLoS One. 7: e42100 (2012).
Romero E, Velez de Mendizabal N, Cendros JM, Peraire C, Bascompta E, Obach R, Troconiz I. Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer. J Pharmacol Exp Ther. 342: 788-798 (2012).
Garrido MJ, Cendrós JM, Ramis J, Peraire C, Obach R, Trocóniz IF. Pharmacodynamic modeling of the effects of Lanreotide Autogel on growth hormone and insulin-like growth factor 1. J Clin Pharmacol. 52: 487-498 (2011).
Soto E, Haertter S, Koenen-Bergmann M, Staab A, Trocóniz IF. Population in vitro-in vivo correlation model for pramipexole slow-release oral formulations. Pharm Res. 27: 340-349 (2010).
Parra-Guillén ZP, González-Aseguinolaza G, Berraondo P, Trocóniz IF. Gene therapy: a pharmacokinetic/pharmacodynamic Overview. Pharm Res. 27: 1487-1497 (2010).
Soto E, Staab A, Freiwald M, Munzert G, Fritsch H, Döge C, Trocóniz IF. Prediction of neutropenia-related effects of a new combination therapy with the anticancer drugs BI 2536 (a Plk 1 inhibitor) and premetrexed. Clin Pharmacol Ther. 88: 660-667 (2010)
Moreno D, Zalba S, Navarro I, Tros de Ilarduya C, Garrido MJ. Pharmacodynamics of cisplatin-loaded PLGA nanoparticles administered to tumor-bearing mice. Eur J Pharm Biopharm. 74: 265-74 (2010).
Berraondo P, González-Aseguinolaza G, Trocóniz IF. Semi-mechanistic pharmacodynamic modelling of gene expression and silencing processes. Eur J Pharm Sci. 37: 416-426 (2009).
Plan EL, Maloney A, Trocóniz IF, Karlsson MO. Performance in population models for count data, part I: maximum likelihood approximations. J Pharmacokinet Pharmacodyn. 36: 353-366 (2009).
Trocóniz IF, Plan EL, Miller R, Karlsson MO. Modelling overdispersion and Markovian features in count data. J Pharmacokinet Pharmacodyn. 36: 461-477 (2009).
Beier H, Garrido MJ, Christoph T, Kasel D, Trocóniz IF. Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antinociceptive response in the presence of competitive antagonism: the interaction between tramadol and its active metabolite on mu-opioid agonism and monoamine reuptake inhibition, in the rat. Pharm Res. 25: 1789-1797 (2008).
Bueno L, de Alwis DP, Pitou C, Yingling J, Lahn M, Glatt S, Trocóniz IF. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice. Eur J Cancer. 44: 142-150 (2008).
Trocóniz IF, Wolters JM, Tillmann C, Schaefer HG, Roth W. Modeling the anti-migraine effects of BIBN 4096 BS, a new calcitonin gene-related peptide receptor antagonist. Clin Pharmacokinet 45: 715-728 (2006).
Garrido MJ, Valle M, Campanero MA, Calvo R, Trocóniz IF. Modelling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. J Pharmacol Exp Ther. 295: 352-359 (2000).
Trocóniz IF, DeAlwish D, Tillmann C, Callies S, Schaefer HG. Comparison of manual versus ambulatory blood pressure measurements with pharmacokinetic/pharmacodynamic modelling of antihypertensive compounds: application to moxonidine. Clin Pharmacol Ther. 68: 18-27 (2000).
Trocóniz IF, Armenteros S, Planelles M, Benítez J, Calvo R, Domínguez R. Pharmacokinetic/pharmacodynamic modelling of the antipyretic effects of two formulations of ibuprofen. Clin Pharmacokinet. 38: 505-518 (2000).
Garrido MJ, Valle M, Calvo R, Trocóniz IF. Altered plasma and brain disposition and pharmacodynamics effects of methadone in withdrawal rats. J Pharmacol Exp Ther. 288: 179-187 (1999).