Project nº 1 - ASIGNADO
Title: Multiplex bioimaging of single-cells using spatially resolved analysis and computational pathology
Director: Carlos E de Andrea · Codirector: José Echeveste

Project nº 2 - ASIGNADO
Title: Targeting inflammation in heart failure with preserved ejection fraction
Director: Arantxa González Miqueo

Project nº 3 - ASIGNADO
Title: New therapeutic strategies for liver cancer
Director: Carmen Berasain · Codirector: María Arechederra

Project nº 4
Title: Implication of GLP-1 in the onset of pancreas steatosis and inflammation: a translational study in preclinical models and patients with obesity and type 2 diabetes
Director: Amaia Rodríguez · Codirector: Gema Frühbeck

Project nº 5
Title: Validation of factors improving CAR T cell function combining CRISPR-based editing tools and next generation sequencing
Director: Juan Roberto Rodríguez Madoz

Project nº 6
Title: Development of chimeric AAVs for Tissue Targeting
Director: Rafael Aldabe

Project nº 7
Title: High-throughput screening to identify bifunctional immunostimulatory drugs in tumor samples
Director: Pedro Berraondo · Codirector: Fernando Aranda

Project nº 8
Title: Role of denitrification in Brucella pathogenesis
Director: Amaia Zúñiga · Codirector: Raquel Conde

Project nº 9 - ASIGNADO
Title: Mimetic periosteum: Functionalization strategies for efficient bone regeneration
Director: Froilán Granero

Project nº 10
Title: Changes in brain perfusion after habitual physical exercise
Director: Javier Bernácer · Codirector: Martín Martínez

Project nº 11 - ASIGNADO
Title: Role of antimicrobial peptides in regulating inflammation and intestinal barrier integrity in the context of obesity
Director: Victoria Catalán · Codirector: Javier Gómez Ambrosi

Project nº 12 - ASIGNADO
Title: Unravelling the complexity of drug resistance development in ovarian cancer: analysis of cellular and molecular mechanisms involved in acquired PARP inhibitors resistan
Director: Beatriz Tavira · Codirector: Antonio González-Martín

Project nº 13
Title: Phenotypic and functional characterization of the immune cell repertoire in patients with myelodysplastic syndromes
Director: Irene Gañán

Project nº 14
Title: Impact of astrocytic insulin receptor ablation on astrocytic calcium dynamics
Director: Maite Solas

Project nº 15 - ASIGNADO
Title: Implementation of new fluorescence tag approaches for tracking cell-cell interactions in the tumor microenvironment
Director: Álvaro Teijeira

Project nº 16
Title: Generation of a multiplexed AAV reporter library for rare disease and cancer gene therapy
Director: Carmen Unzu · Codirector: Juan Dubrot

Project nº 17
Title: Deciphering the cellular complexity of the human bone marrow microenvironment and its involvement in aging and pathogenesis of multiple myeloma
Director: Isabel Calvo

Project nº 18 - ASIGNADO
Title: Engineering of AAV-Based Vectors in combination with Radiotherapy for Immuno-gene Therapy of Cancer
Director: Juan Dubrot

Project nº 19 - ASIGNADO
Title: Inhibition of caspase-2 activity to fight metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma development
Director: Amaya López · Codirector: Maite García

Project nº 20 - ASIGNADO
Title: New Epigenetic Mechanisms and Innovative Therapeutic Interventions in Hepatocellular Carcinoma
Director: Maite García · Codirector: Amaya López

Project nº 21
Title: Vaccination to improve the efficacy of CAR-T cells sin solid tumors
Director: Sandra Hervás

Project nº 22
Title: Investigating transthyretin amyloid cardiomyopathy through advanced disease modeling
Director: Olalla Iglesias · Codirector: Manuel Mazo

Project nº 23  - ASIGNADO
Title: Biofabrication of human cardiac valves with hiPSC-derived cells and 3D printing
Director: Manuel Mazo

Project nº 24
Title: Novel strategies to overcome immunotherapy resistance in NSCLC
Director: Alfonso Calvo · Codirector: Diego Serrano

Project nº 25
Title: Dissection of immunodynamics in metastatic lung cancer for personalized immunotherapy
Director: Fernando Lecanda

Project nº 26
Title: Identification and therapeutic validation of novel radiosensitizers and immune boosters in breast cancer
Director: Rafael Martínez · Codirector: Fernando Lecanda

Project nº 27
Title: Role of the scavenger receptor MARCO in the progression of chronic liver disease and hepatocarcinogenesis
Director: Jesús María Bañales · Codirector: María Jesús Perugorria

Project nº 28
Title: Senescent T-cell biomarkers to select the best T cell Receptors for T-cell Therapy
Director: Marta Montes · Codirector: Sandra Hervás

Project nº 29
Title: Development of sensibilizing therapies for the treatment of radioresistant NSCLC tumors
Director: Diego Serrano · Codirector: Alfonso Calvo

Project nº 30
Title: Generating self-amplifying RNA vectors able to propagate through the generation of extracellular vesicles for cancer therapy
Director: Cristian Smerdou

Project nº 31 - ASIGNADO
Title: Optimizing CAR-T cell therapy for breast cancer using immunomodulatory phytomedicines
Director: Maritza García

Project nº 32
Title: Identification of key transcriptional regulators as novel therapeutic targets in myeloid malignancies
Director: Teresa Ezponda · Codirector: Paula García 

Project nº 33
Title: Targeting the myeloid compartment to improve immunotherapy of hepatocelular carcinoma
Director: Pablo Sarobe · Codirector: Diana Llopiz

Project nº 34
Title: Targeting RNAi to the liver using aptamers for precision gene therapy in hepatocellular carcinoma
Director: Beatriz Moreno · Codirector: Fernando Pastor

Project nº 35
Title: Blockade of an RNA surveillance mechanism in resilient tumor cells to counteract antigen immune escape and tumor relapse
Director: Fernando Pastor · Codirector: Beatriz Moreno

Project nº 36 - ASIGNADO
Title: Translational biomarkers for the evaluation of neuromodulation strategies
Director: Miguel Valencia

Project nº 37 - ASIGNADO
Title: Plasma biomarkers predictive of Parkinson's disease in prodromal phases: proteomic study
Director: Maria Cruz Rodríguez Oroz

Project nº 38
Title: Effects of cell isolation techniques in cell viability and expression
Director: Iván Cortés · Codirector: Carlos Ortiz de Solórzano

Project nº 39
Title: Occult hepatitis B virus infection: diagnostic strategy and estimated prevalence
Director: Alejandra Pérez · Codirector: Gabriel Reina

Project nº 40
Title: Mechanisms of action of Immunotherapy with TLR3 agonists
Director: Ignacio Melero · Codirector: Laura Mosteo

Project nº 41 - ASIGNADO
Title: Production of multifuncitonal polymeric wound dressings by solution blow spinning for the treatment of Leishmaniasis
Director: Paul Nguewa · Codirector: Gustavo González Gaitano

Project nº 42
Title: Self-Assembled Photoswitchable Fluorescent Bacteria for Information Encoding
Director: Juan Pablo Fuenzalida · Codirector: Gustavo González Gaitano

Project nº 43 - ASIGNADO
Title: Brain-immune system interactions in major depression:role of HDAC5 in prefrontal cortex neurons and myeloid cells
Director: Rosa M. Tordera · Codirector: Elisa Mengual

Project nº 44
Title: Study of the effect of proton therapy at the myocardial level and its possible cardiotoxicity
Director: Manuel García de Yébenes · Codirector: Ana de La Fuente

Project nº 45
Title: Mycotoxins and cancer 
Director: Elena González Peñas

Project nº 46 - ASIGNADO
Title: Characterization of innate immunity in blood samples from amyotrophic lateral sclerosis (ALS)
Director: Ivonne Jericó · Codirector: Marisol Aymerich

Project nº 47 - ASIGNADO
Title: Breaking Bacterial Silence: Activating Dormant BGCs in Xenorhabdus nematophila for Antimicrobial Innovation
Director: Tomás Maira

Project nº 48 - ASIGNADO
Title: Development and characterizarion of new vectors for cancer immunotherapy
Director: Rubén Hernández Alcoceba · Codirector: Juan Dubrot Armendáriz

Project nº 49 - ASIGNADO
Title: Post-protonterapy lymphopenia: Focal brain versus craniospinal irradiation predictive models
Director: Dr. Felipe Calvo. Codirector: Dra. Rosa María Meiriño

Project nº 50 - ASIGNADO
Title: Methods for the evaluation of interventional studies in Neurosciences
Director: Dr. Martín Martínez Villar. Codirector: Dr. Miguel Valencia Ustárroz

Project nº 51 - ASIGNADO
Title: Brain PET with 18F-FDG in the diagnosis of autoimmune encephalitis: syndromic and antibody-based patterns
Director: Dr. Javier Arbizu. Codirector: Dra. Elena Prieto

Project Nº  01 ASIGNADO
Title: Development of trans-complementation strategies for supplementation of large genes in the brain

Project Nº 02
Title:  Discovering pathways for immunogenicity in Liver Cancer through hampering protein folding

Project Nº 03
Title: Implication of adipo-myokines in the onset of sarcopenic obesity and its associated comorbidities in preclinical models and patients with obesity and type 2 diabetes

Project Nº 04 ASIGNADO
Title: Role of SLU7 in carcinogenesis: from epigenetics to protein stability (SLUTOME).

Project Nº 05
Title: Deciphering the cellular complexity of the human bone marrow microenvironment and its involvement in aging and pathogenesis of multiple myeloma

Project Nº 06
Title: Interpretable deep learning model to predict mutations in lung adenocarcinomas from haematoxylin and eosin-stained (H&E) whole-slide images

Project Nº 07 ASIGNADO
Title: Overcoming resistance to oncolytic viruses in pediatric brain tumors

Project Nº 08
Title: A descriptive analysis of the malaria burden in pregnancy and newborns in the Monkole General Hospital in Kinshasa, Democratic Republic of Congo

Project Nº  09
Title: Design, synthesis and application of novel hydrogels for cardiovascular tissue engineering

Project Nº 10 ASIGNADO
Title: Unravelling the complexity of drug resistance development in ovarian cancer: analysis of cellular and molecular mechanisms involved in acquired PARP inhibitors resistance in syngeneic animal models

Project Nº 11
Title: Role of microglial SIRT2 enzyme in neurodegenerative diseases

Project Nº 12
Title: In vitro and in vivo validation of tumor-specific T cell receptors identified by molecular signatures. A new approach for adoptive T-cell therapy.

Project Nº 13
Title: Impact of astrocytic insulin receptor ablation on astrocytic calcium dynamics

Project Nº 14
Title: Vaccination to improve the efficacy of CAR-T cells in Glioblastoma

Project Nº 15 ASIGNADO
Title: Understanding resistance to immunotherapy in pancreatic cancer

Project Nº 16
Title: Advanced hydrogels for the delivery of CAR-T therapies in solid tumors

Project Nº 17
Title: High risk of liver cancer in acute hepatic porphyrias: Is the porphobilinogen deaminase a new metabolic tumor suppressor gene in hepatocellular carcinoma?

Project Nº 18
Title: Modulation of innate immune response to potentiate lung cancer immunotherapy.

Project Nº 19
Title: Targeting inflammation in heart failure with preserved ejection fraction

Project Nº 20
Title: Optimization of co-treatment with small-molecule vegfr3 inhibitors and immunotherapy for the treatment of aggressive breast cancer

Project Nº 21
Title: Molecular characterization of Listeria monocytogenes clinical strains isolated in Navarra

Project Nº 22
Title: Enzymatic and hormonal mechanisms involved in controlling nitrate levels in leafy vegetables

Project Nº 23
Title: Valorization of vegetable organic wastes for health purposes

Project Nº 24
Title: Fabrication of human cardiac tissue using novel biofabrication technologies

Project Nº 25 ASIGNADO
Title: Validation of relevant factors influencing CAR T cells activity using CRISPR/Cas9-based genome editing tools

Project Nº 26 ASIGNADO
Title: Unveiling new vulnerabilities in KRAS-driven cancers to design novel therapeutic strategies

Project Nº 27 ASIGNADO
Title: Improved CART cell design to overcome physical, chemical and cellular barriers found in the tumor microenvironment.

Project Nº 28
Title: RNA-targeted therapeutics to sensitize tumor cells to immunotherapy

Project Nº 29 ASIGNADO
Title: Understanding the mechanisms of circulating tumor cells (CTCs) to evade the immune response in cancer immunotherapy

Project Nº 30
Title: Unraveling the Pathophysiological role or pigr in cholangiocarcinoma

Project Nº 31
Title: Exploring microproteins to unveil novel anticancer therapies

Project Nº 32
Title: Mimetic periosteum for controlled release of antibiotics and osteogenic growth factors in the treatment and prevention of osteomyelitis

Project Nº 33
Title: Role of long non-coding RNAs in ovarian cancer senescence

Project Nº 34 ASIGNADO
Title: Development of chimeric AAVs to enhance Immune Evasion and Tissue Targeting

Project Nº 35 ASIGNADO
Title: Identification of immunotherapeutic combinations for the treatment of hepatocellular carcinoma

Project Nº 36
Title: Identification of essential epigenetic genes and development of Epi-DRUGs for the cure of Multiple Myeloma

Project Nº 37
Title: Identification of new therapeutic targets for Parkinson disease

Project Nº 38 ASIGNADO
Title: IL-1β receptor inhibition as a new therapeutic approach for Alzheimer's disease

Project Nº  39
Title: Molecular ROUTER, a method to control the expression of therapeutic genes with common drugs

Project Nº  40
Title: Engineering RNA devices for novel antitumor RNA immunotherapy

Project Nº 42 ASIGNADO
Title: Development of a new mRNA delivery system for cancer gene therapy based on viral particles

Project Nº 43
Title: Role of the scavenger receptor MARCO in the progression of chronic liver disease and hepatocarcinogenesis: new diagnostic, prognostic and therapeutic strategy

Project Nº  44
Title: Role of KLF transcription factors in the pathogenesis of non-alcoholic fatty liver disease pathogenesis and liver cancer

Project Nº  45
Title: Identification of gene regulatory networks guiding aberrant hematopoiesis in myeloid malignancies using single-cell RNA sequencing

Project Nº 46
Title: Does RNA encode the molecular memory of stress episodes?

Project Nº 47 ASIGNADO
Title: Identification of the interactome of alpha-synuclein, a protein with a key role in Parkinson´s disease

Project Nº 48 ASIGNADO
Title:  Evaluation of the electric response to viral treatment in pediatric brain tumors

Project Nº 49
Title:  Modulation of the Integrated Stress Response as a therapeutic target for Amyotrophic Lateral Sclerosis treatment

Project Nº  50 ASIGNADO
Título: Deciphering the molecular mechanisms involved in copper toxicity

Project Nº 51
Title: Development of novel AAV vectors for precision gene medicine of congenital hearing loss

Project Nº 52
Title: Safety and efficacy of CAR-TCD19 cell therapy in refractory lupus nephritis patients

Project Nº 53
Title:  CRISPRCas screening analyses for the study of the epigenetic regulation of fibrosis in myocardial infarction

Project Nº 54 ASIGNADO
Title: Design and fabrication of an Air-liquid microfluidic device for grown tumoral organoids

Project Nº 55
Title: The role of poly-N-acetyl-glucosamine (PNAG) in Serratia marcescens: biofilm formation, resistance to serum killing, and phagocytosis by polymorphonuclear cells

Project Nº56 ASIGNADO
Title: TDP-43 pathology propagation in ALS and FTD cell based models

Project Nº57 
Title: Characterization of therapeutic vectors for the treatment of cancer

Project Nº58 ASIGNADO
Title: Vaccination to improve the efficacy of CAR-T cells sin solid tumors

Project Nº 01
Title: Study of innate immune system impact on drug response in murine ovarian cancer models 
 
Project Nº 02
Title: Unraveling the link between epigenetics and RNA splicing in cancer

Project Nº 03
Title: Redesigning the impact of radiotherapy in breast cancer with new players: Role of Circulating Tumor Cells (CTCs) and Enpp1-based vulnerabilities

Project Nº 04
Title: Role of the SIRT2 enzyme in microglial function and its implication in neurodegenerative diseases
 
Project Nº 05
Title: Transcriptomic (RNAseq and microRNAseq) and proteomic analysis of circulating Extracellular vesicles (liquid biopsy) for novel biomarker and therapeutic target discovery in vascular pathologies and diabetes

Project Nº 06
Title: Deciphering the role of astrocytic GLUT1 in Alzheimer’s disease

Project Nº 07 - ASIGNADO
Title: 3D bioprinting of functional human cardiac

Project Nº 08
Title: Inducible expression for gene therapy

Project Nº 09 ASIGNADO
Title: Microproteins as a new source of anticancer vaccines

Project Nº 10
Title: Reprograming Leishmania permissive macrophages with nanoparticles
 
Project Nº 11
Title: Development of DNA trans-complementation strategies for expression of large genes in the brain
 
Project Nº 12 ASIGNADO
Title: Modulation of innate immune response to potentiate lung cancer immunotherapy

Project Nº 13
Title: Identification of transcriptional lesions guiding aberrant hematopoiesis in myelodysplastic syndromes using single-cell RNA sequencing

Project Nº 14
Title: Role of the scavenger receptor MARCO in the progression of chronic liver disease and hepatocarcinogenesis: new diagnostic, prognostic and therapeutic strategy

Project Nº 15 ASIGNADO
Title: Vaccination to improve the efficacy of CAR-T cells sin solid tumors

Project Nº 16 ASIGNADO
Title: Development of RNA viral vectors able to express new immunostimulatory molecules for cancer gene therapy

Project Nº 17 ASIGNADO
Title: In vitro and in vivo assessment of the myocardial antifibrotic effect of a novel epigenetic regulation inhibitor

Project Nº 18
Title: Actionable neutrophil-associated mechanisms in immunotherapy that interfere with T-cell crosspriming in the tumor microenvironment

Project Nº 19 ASIGNADO
Title: Implication of guanylin peptides in the onset of pancreas steatosis and inflammation: a translational study in preclinical models and patients with obesity and type 2 diabetes
  
Project Nº 20 ASIGNADO
Title:  Unleashing tumor immunity by inferring RNA surveillance mechanisms that operate in malignant cells

Project Nº 21
Title: Validation of a Microfluidic device for CTCs sorting based on dielectrophoresis forces

Project Nº 22
Title: Immune system antitumor response enhanced by IL12 mRNA encapsulated into nanoparticles

Project Nº 23 ASIGNADO
Title: Identification of Novel Factors of Klebsiella pneumoniae Required for Macrophage Survival Using Transposon Sequecing (Tn-seq) Analysis

Project Nº 24
Title: Transcriptomic analysis of thrombi extracellular vesicles for the identification of new biomarkers and therapies to improve diagnosis and prognosis in ischemic stroke patients

Project Nº 25
Title: Assessment of cerebrovascular reactivity using magnetic resonance imaging

Project Nº 26 ASIGNADO
Title: Development of Epi-PROTACs for the cure of Multiple Myeloma

Project Nº 27 ASIGNADO
Title: CAR-expressing macrophages as adoptive cell therapy for solid tumors 

Project Nº 28
Title: Evaluation of the therapeutic potential of protein-based nanoparticles 
 
Project Nº 29
Title: Finding genetic susceptibilities to overcome radioresistance in cancer
 
Project Nº 30 ASIGNADO
Title: Creation and characterization of cellularized patches  for the treatment of myocardial infarction

Project Nº 31
Title: In vitro studies of the polymyxin E nonapeptide for a new combination therapy against β-lactam resistant bacteria

Project Nº 32 ASIGNADO
Title: Development of novel AAV vectors for the treatment of Cx26 deficiency
 
Project Nº 33 ASIGNADO
Title: Translational biomarkers for the evaluation of neuromodulation strategies

Project Nº 34 ASIGNADO
Title: Identification of neoantigens in multiple myeloma to develop personalized vaccines

Project Nº 35
Title:  Inducible CAR-T cells to fine tune the antitumor activity reducing toxicity

Project Nº 36
Title: Creation of a risk stratification model in initial prostate carcinoma based on machine learning and radiomics on PET-PSMA images

Project Nº 37    
Title: 3D biomaterials and miRNAs for cardiac repair after myocardial infarction 

Project Nº 38
Title: Nanoparticles for RNA cancer therapy
 
Project Nº 39
Title: Mimetic autografts functionalization with nanoparticles for a customized treatment of pseudoarthrosis 

Project Nº 40
Title: Optimization of autologous customized engineering auricula reconstruction for the treatment of microtia 

Project Nº 41 ASIGNADO
Title: Novel cellular strategies to improve immunotherapy:  targeting amino acid transporters on T cells

Project Nº 42
Title: Studying the role of the lncRNA Linc01133 in cancer senescence

Project Nº 43 
Title: Emerging Infectious Diseases: Therapeutics development and assay

Project Nº 44
Title: Modulation of adipokines  release by ω-3 fatty acids: effects on GLUT12 expression in breast cancer

Project Nº 45
Title: Role of KLF transcription factors in the pathogenesis of non-alcoholic fatty liver disease pathogenesis and liver cancer

Project Nº 46
Title: Deciphering the role of PRDM1 in adipocyte function and obesity susceptibility

Project Nº47 ASIGNADO
Title:  New ways to modulate the ISR as potential therapies for ALS

Project Nº48 ASIGNADO
Title: Exploring the pathogenic role of fatty-acid and cholesterol metabolism in pre-clinical mouse models of B-cell lymphomas

Project Nº 49 ASIGNADO
Title: Production and biological evaluation of multifunctional poymeric fibres by solution blow spinning for the treatment of cutaneous infections including leishmaniasis

Project Nº50
Title: Project title: 3D Bioengineered matrices for tumor models

Project Nº 51 ASIGNADO
Title: Leishmanicidal activities of repurposed compounds

Project Nº52
Title:  Pit-stop in cancer inmunotherapy: conditioning tumor microenvironment by selective targeting tumor associated macrophages

Project Nº 53 ASIGNADO
Title: A CRISPR/Cas9-based functional screen to identify KRAS-dependent genes sensitizing to radiotherapy

Project Nº 54 ASIGNADO
Title: Evaluation of the antitumor effect of Paxalisib in combination with the oncolytic adenovirus Delta-24-RGD for pediatric brain tumors

Project Nº 55 ASIGNADO
Title: Analysis of the anti-parkinsonian effect of immunomodulatory compounds

Project Nº 56 ASIGNADO
Title: Patrones de neurodegeneración mediante PET con 18F-FDG en los parkinsonismos atípicos

Project Nº 01
Title: Validating plasma microRNAs as biomarkers of Alzheimer´s disease: a clinical, neuroimaging and molecular genetic study

Project: Nº 02
Title: Spatial analysis of tissues: cellular positioning and cell-cell interactions in multiplexed histological images

Project: Nº 03 - ASIGNADO
Title: Unraveling the link between epigenetics, RNA transcription and splicing in cancer

Project: Nº 04 - ASIGNADO
Title: Brain Metabolic signatures in primary progressive aphasia variants

Project: Nº 05
Title: GENETIC DRONES: Development of chimeric gene therapy vectors to treat renal diseases

Project: Nº 06
Title: Impact of astrocytic insulin receptor on Alzheimer’s disease

Project: Nº 07
Title: Multimodal study of preclinical synaptic changes in Parkinson’s disease

Project: Nº 08
Title: Development of immunomodulatory nasal therapies in an animal model of progressive parkinsonism

Project: Nº 09 - ASIGNADO
Title: Retromutation and knowdown of SgK496 in lung squamous cell carcinoma (LUSC) cell

Project: Nº 10
Title: Effects of a hypothermic mimetic on neuroinflammation

Project: Nº 11 - ASIGNADO
Title: Bioorthogonal modification of natural polymers for the development of new biomaterials for tissue engineering

Project: Nº 12 - ASIGNADO
Title: What experimental models tell us about the neuroinflammatory reaction that occurs in Parkinson´s disease

Project: Nº 13
Title: Modulation of innate immune response to potentiate lung cancer immunotherapy

Project: Nº 14 - ASIGNADO
Title: Implementation of murine ovarian cancer model based on ID-8 cell line

Project: Nº 15 - ASIGNADO
Title: Diagnostic and therapeutic insights from the analysis of plasma extracellular vesicles in heart failure patients

Project: Nº 16 - ASIGNADO
Title: Identification of novel epigenetic targets and development of new epigenetic inhibitors for the cure of Multiple Myeloma

Project: Nº 17
Title: Development of improved CAR T cells for immunotherapy against Multiple Myeloma

Project: Nº 18 - ASIGNADO
Title: Novel strategies to overcome immunotherapy resistance in NSCLC

Project: Nº 19 - ASIGNADO
Title: Role of YES1 in small cell lung cancer

Project: Nº 20 - ASIGNADO
Title: Metabolic alterations in cancer cells and their implication in immunotherapy

Project: Nº 21
Title: Optimization of cellular and biological treatments by composite fabrication and controlled release from mimetic periosteum scaffolds

Project: Nº 22
Title: Implication of guanylin and uroguanylin in the onset of obesity-associated inflammation: a translational study

Project: Nº 23
Title: Humanization of high-affinity T cell receptors (TCR) developed in nontolerant nonhuman hosts to exploit TCR-therapy targeting shared tumour antigens

Project: Nº 24 - ASIGNADO
Title: Combinatorial Immunotherapies in sarcomas in a novel GEMM platform

Project: Nº 25
Title: RNA aptamers for cancer immunotherapy

Project: Nº 26
Title: The role of the STING pathway in the mechanisms involved in anti-PD-1 treatment resistance in patients with STK11/LKB1 mutant NSCLC

Project: Nº 27
Title: Drug combinations to potentiate the antitumor activity of KRAS inhibitors in cancers with distinct mutational landscape

Project: Nº 28
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project: Nº 29
Title: Role of interleukin-1b in the infiltration and polarization of macrophages in adipose tissue

Project: Nº 30
Title: Assessment of cerebrovascular reactivity using magnetic resonance imaging

Project: Nº 31
Title: Design, synthesis and biological evaluation of novel selenocompounds as antitumoral agents

Project: Nº 32
Title: Optimization of methods to produce High-Capacity Adenoviral vectors for gene therapy applications

Project: Nº 33
Title: Metabolic profile improvement associated with bariatric surgery

Project: Nº 34
Title: Epigenetic deregulation of endogenous retroviral genes in the origin of human cancers

Project: Nº 35 - ASIGNADO
Title: Understanding the tumor microenvironment of pediatric brain tumors

Project: Nº 36
Title: Armed Oncolytic viruses for the treatment of pediatric brain tumors

Project: Nº 37
Title: Adjuvant treatment with anti-VEGFR3 to improve success of combined radio- and immunotherapy in breast cancer

Project: Nº 39
Title: Synthesis and biological evaluation of new nitric oxide donors as antimicrobial agents

Project: Nº 40
Title: Role of denitrification in Brucella pathogenesis

Project: Nº 41 - ASIGNADO
Title: Emerging Infectious Diseases: Diagnostics/Therapeutics development and assay

Project: Nº 42
Title: Mechanobiology for cardiac regeneration

Project: Nº 43
Title: Biotechnological modification of RNA levels for anticancer RNA vaccines

Project: Nº 44
Title: Role of KLF transcription factors in the pathogenesis of non-alcoholic fatty liver disease pathogenesis and liver cancer.

Project: Nº 45
Title: Role of post-transcriptional modifications (PTMs) in the crosstalk between cholangiocarcinoma and its micro-environment

Project Nº 46
Title: Treatment of intracellular pathogens with tailored and immunomodulatory nanomedicines: an strategy for decreasing risk of antimicrobial resistances

Project: Nº 47
Title: Nanovectors for oncology encapsulating nucleic acid (DNA/RNA)

Project: Nº 48
Title: Development of RNA viral vectors able to express new immunostimulatory molecules for cancer gene therapy

Project: Nº 49
Title: In vitro and in vivo assessment of the myocardial antifibrotic effect of a novel epigenetic regulation inhibitor

Project: Nº 50
Title: Identification of transcriptional lesions guiding aberrant hematopoiesis in myelodysplastic syndromes using single-cell RNA sequencing

Project: Nº 51
Title: Validation of a Microfluidic device for CTCs sorting based on dielectrophoresis forces

Project: Nº 52
Title: Investigating the role of lncRNAs in cancer cell division

Project: Nº 53
Title: HLA-G/ILT4 exosomes as a new target in cancer immunotherapy

Project: Nº 54 - ASIGNADO
Title: Embedding of drugs in polymeric fibres for dermal release: application to the treatment of cutaneous leishmaniasis

Project Nº 55 - ASIGNADO
Title: Role of NADPH Oxidase 5 in angiotensin II-induced hypertension

Project Nº 56 - ASIGNADO
Title: Development of a genetic test for early detection and prevention of Molar-Incisive
Hypomineralization (MIH)

Project Nº 01
Title: Role of adipose tissue miRNAs in obesity and weight loss

Project Nº 02
Title: Unraveling the link between epigenetics and RNA splicing in cancer

Project Nº 03
Title: Impact of astrocytic insulin receptor on glucose uptake and cognition

Project Nº 04
Title: GENETIC DRONES: Development of renal gene therapy vectors to treat

Project Nº 05
Title: Implication of guanylin and uroguanylin in the onset of obesity and its associated comorbidities: a translational study

Project Nº 06
Title: Exploring the link between obesity and the risk of dementia

Project Nº 07 ASIGNADO
Title: Enhancing the efficacy of CAR T-cell Therapy for the treatment of solid tumors

Project Nº 08
Title: Novel epigenetic strategies for the treatment of liver tumors

Project Nº 09
Title: Assessment and prevention of chemotherapic-related cardiotoxicity using cell reprogramming and tissue engineering

Project Nº 10
Title: Role of the scavenger receptor MARCO in liver disease: new diagnostic, prognostic and therapeutic strategy

Project Nº 11
Title: Role of miR-506 in the regulation of the liver- and immunophenotype in primary biliary cholangitis

Project Nº 12 ASIGNADO
Title: Understanding mechanims of synergy in CD137-based cancer immunotherapy

Project Nº 13
Title: Role of interleukin-1B in the infiltration and polarization of macrophages in adipose tissue

Project Nº 14 ASIGNADO
Title: Mechanisms and antileukemic efficacy of combined therapies based on the functional activation of PP2A in acute myeloid leukemia. Role of PP2A regulatory subunits as specific targets

Project Nº 15
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project Nº 16
Title: Development of new therapeutic alternatives against HDV infection based on RNA editing strategies

Project Nº 17
Title: Design, synthesis and biological evaluation of novel selenides as antitumoral agents

Project Nº 18
Title: New approaches of CAR-T therapy against the tumour microenvironment

Project Nº 19
Title: Unfolded protein response and myocardial fibrosis in heart failure

Project Nº 20
Title: Improving CART cell therapies for hematological malignances: from innovative CAR designs to modulation of molecular mechanisms

Project Nº 21 ASIGNADO
Title: Role of the autocrine IL-10/STAT3 cascade in the pro-survival signalling and anti-tumour immune evasion of diffuse large B-cell lymphomas

Project Nº 22
Title: Effect of Sirtuin2 inhibition in a transgenic mouse model of Alzheimer disease

Project Nº 23 ASIGNADO
Title: Development of new epigenetic inhibitors for the cure of Multiple Myeloma

Project Nº 24
Title: Understanding Tumor Initiation using 3D organoid models, microfluidics and advanced three-dimensional microscopy

Project Nº 25 ASIGNADO
Title: Translational biomarkers for the evaluation of physical/pharmacological neuromodulation strategies

Project Nº 26
Title: Amylin as a therapeutic target in Parkinson's disease

Project Nº 27
Title: New antigen targets for vaccination in hepatocellular carcinoma: identification of T cell epitopes from micropeptides derived from long non-coding RNAs

Project Nº 28_ASIGNADO
Title: Resting-state fMRI in presurgical mapping

Project Nº 29
Title: Riboswitches for therapeutic expression

Project Nº 30
Title: Nonsense Mediated mRNA Decay (NMD) as an antigen immune-checkpoint

Project Nº 31
Title: Contribution of altered transcrtiptional regulators to the phenotype of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Project Nº 32
Title: Brain Metabolic signatures in primary progressive aphasia variants

Project Nº 33
Title: Effects of a hypothermic mimetic on brain insulin pathway

Project Nº 34
Title: Biofabrication of a human Achilles tendon

Project Nº 35
Title: Study of the early synaptic changes in Parkinson’s disease

Project Nº 36
Title: Optimization of brain biodistribution of high-capacity adenoviral vectors

Project Nº 37
Title: Optimization of rhBMP-2 treatments by composite fabrication and controlled release from mimetic periosteum scaffold

Project Nº 38
Title: New therapeutic combinations against KRAS-driven non-small cell lung cancer (NSCLC). Study of new biomarkers of response to anti-PD-1 therapy

Project Nº 39
Title: In vitro and in vivo assessment of the myocardial antifibrotic effect of a novel epigenetic regulation inhibitor

Project Nº 40
Title: Investigating the role of lncRNAs in cancer cell division

Project Nº 41
Title: A genome-wide approach to discover small circular RNAs under physiological and stress conditions

Project Nº 42 ASIGNADO
Title: Characterization of the role of DYSTYK, a dual serine/threonine tyrosine kinase and in non-small cell lung cancer

Project Nº 43
Title: Deciphering the role of PRDM1 in adipose tissue transcriptome and obesity susceptibility

Project Nº 44
Title: Metabolic profile improvement associated with bariatric surgery

Project Nº 45
Title: Design of nanoparticles for the local treatment of cutaneous leishmaniasis

Project Nº 46
Title: Development of a hydrogel containing a novel diselenide for the topical treatment of localized cutaneous leishmaniasis

Project Nº 47
Title: Development of novel strategies to potentiate lung cancer immunotherapy

Project Nº 48
Title: Anti-drug-antibodies (ADA) as a mechanism of acquired resistance in cancer immunotherapy

Project Nº 49
Title: Identificantion of candidate genes conferring resistance to dementia in the context of Alzheimer´s Disease

Project Nº 50  ASIGNADO
Title: Molecular and cellular mechanisms underlying Amyotrophic Lateral Sclerosis

Project Nº 51
Title: Clinical Utility of a Comprehensive Next-Generation Sequencing Panel for Hereditary Cancer Syndromes

Project Nº 52
Title: Protein-based nanoparticles for the delivery of bevacizumab

Project Nº 53
Title: Transcriptomic analysis (RNAseq) of endothelial extracellular vesicles (EndEVs) in patients with cardiovascular diseases

Project Nº 54
Title: Characterization of the role of PRDM1 and CDK2 in lipid and glucose metabolism in cultured adipocytes

Project Nº 55
Title Adjuvant treatment with anti-VEGFR3 to improve success of immunotherapy in breast cancer

Project Nº 56 ASIGNADO
Title: From single molecule mRNA visualization in living cells to genetic and proteomic screens: Discovering the composition of transport of the XBP1 ribonucleoprotein  

Project Nº 57 ASIGNADO
Title: Genetically engineered mouse models by Crispr/cas9 genome editing for the screening of cutting-edge immunotherapies

Project Nº1 - ASIGNADO
Title: GENETIC DRONES: Development of renal gene therapy vectors

Project Nº2
Title: Next-generation immune monitoring in multiple myeloma

Project Nº3
Title: Development of novel engineered forms of fibroblast growth factor 21 (FGF21) for the treatment of metabolic syndrome-associated diseases

Project Nº4
Title: Translational biomarkers for the evaluation of physical/pharmacological neuromodulation strategies

Project Nº5
Title: Role of clonal hematopoiesis of indeterminate potential (CHIP) in the pathogenesis and evolution of chronic pulmonary diseases

Project Nº6 - ASIGNADO
Title: Design, synthesis and application of novel biorthogonal hydrogels for cardiac tissue engineering

Project Nº7
Title: Role of GDF15 in the development of obesity-associated insulin resistance and type 2 diabetes

Project Nº8
Title: Role of Cxcl12 in bone regeneration 

Project Nº9
Title: Cell competition as a strategy tro increase interspecies chimerism

Project Nº10
Title: Coupling epigenetics and RNA splicing in cancer

Project Nº11 - ASIGNADO
Title: Neuroinflamation in the alpha‐synuclein models of Parkinson´s disease

Project Nº12
Title: Optimization of gene transfer strategies for brain diseases

Project Nº13
Title: Study of the implication of an oncogenic domain in cell biology of primitive eukaryotic cells

Project Nº14
Title: Role of the mutagenic enzyme AID in the pathogenesis of B-cell lymphomas

Project Nº15
Title: Treatment of hepatocellular carcinoma by targeting the non-coding genome

Project Nº16
Title: Resting state brain networks in mild cognitive impairment and Alzheimer’s disease

Project Nº17 - ASIGNADO
Title: Impact of astrocytic insulin receptor on cognition

Project Nº18
Title: Role of the scavenger receptor MARCO in liver cancer: new diagnostic, prognostic and therapeutic strategy

Project Nº19
Title: Immunogenicity of neoantigens in hepatocellular carcinoma

Project Nº20
Title: Modulation of innate immnune response to potentiate lung cancer immunotherapy

Project Nº21 - ASIGNADO
Title: Elucidating the Mechanism of HDV-induced liver damage

Project Nº22
Title: Design, synthesis and biological evaluation of novel selenides as antitumoral agents

Project Nº23
Title: Mechanisms of long-term CART cell persistence for improved therapeutic efficacy

Project Nº24
Title: Designing nanomedicines for the targeting and activation of Leishmania spp. infected macrophages

Project Nº25
Title: New immunomodulatory combinations against lung adenocarcinoma (LUAD) according to the mutational status of KRAS oncogene. Study of new biomarkers of response to anti-PD-1 therapy

Project Nº26
Title: Role of post-transcriptional modifications (PTMs) in the etiopathogenesis of cholangiocarcinoma: new diagnostic, prognostic and therapeutic strategy

Project Nº27
Title: Impact of thrombus composition on neurovascular damage in ischemic stroke

Project Nº28
Title: Correlate tumor mutation burden with immune signatures and clonality of T cell receptors in human cancers

Project Nº29
Title: Dechipering the role of specific transcriptional regulators in cardiovascular progenitors derived from human iPSCs

Project Nº30
Title: New approaches of adoptive transfer cell therapy for cancer immunotherapy

Project Nº31
Title: Effect of the activation of key molecules for the survival and metabolic fitness of T cells to enhance their antitumor efficacy

Project Nº32
Title: Histological characterization of a diet-induced obese zebrafish (Danio rerio) model   

Project Nº33 - ASIGNADO
Title: Development of new combined therapies in acute myeloid leukemia. Towards a personalized treatment in patients with mutations in the FLT3 tyrosine kinase receptor and overexpression of the SET oncoprotein

Project Nº34
Title: Effects of a high fat diet on adrenomedullin KO mice

Project Nº35
Title: Interplay of adipokines and myokines after bariatric surgery: a translational study

Project Nº36
Title: Identification of tumor exosomes from humanized-Patient-Derived-Xenograft (PDX) model

Project Nº37
Title: Functional changes of the synapse in the beginning and progression of the dopaminergic death

Project Nº38
Title: Metabolic changes associated with bariatric surgery

Project Nº39 - ASIGNADO
Title: Study of molecular mechanisms underlying neurodegenerative diseases like Parkinson's disease  to identify effective therapeutic targets 

Project Nº40
Title: Study of molecular mechanisms underlying neurodegenerative diseases like Parkinson's disease  to identify effective therapeutic targets 

Project Nº41
Title: Cancer Immunotherapy using immunostimulatory aptamers

Project Nº42
Title: Role of adipose tissue miRNAs in obesity and weight loss

Project Nº43
Title: Study of the mechanism of lncRNA function in cancer cells

Project Nº44
Title: EXOSOMES, miRNAs AND LIVER STEATOSIS: DIAGNOSIS AND TARGET GENES

Project Nº45
Title: Adipose tissue, macrophages and immunomodulation. Role of interleukin-1 in infiltration and polarization of macrophages in adipose tissue

Project Nº 46
Title: A genome-wide approach to discover small circular RNAs under physiological and stress conditions

Project Nº 47
Title: Mucus-permeating nanoparticles as carriers for oral delivery of therapeutic proteins  

Project Nº 48
Title: Study of the molecular mechanisms involved in fibroblasts activation and differentiation in Myocardial Infarction

Project Nº 49
Title: GAS6/PROS-TAM pathway inhibition to enhance immune response in T cells-based immunotherapy

Project Nº 50 - ASIGNADO
Title: Intestinal absorptionof transition metals

Project Nº 51 - ASIGNADO
Title: EFFECT OF NADPH OXIDASE 5-MEDIATED OXIDATIVE STRESS ON MATRIX METALLOPROTEINASES

Project Nº 52 - ASIGNADO
Title: Exploring mTOR pathway in the brain and peripheral tissues of p27 KO mice: effect on memory and modulation by high fat diet

Project Nº 53 - ASIGNADO
Title: Enhancing matrix integration and mechanical properties of tissue-engineered cartilage

Project Nº 54 - 
Title: Theranostics of Neuroendocrine Tumors: the role of peptide receptor radionuclides targeting somatostatine receptors

Project Nº55
Title: The added value of Trabecular Bone Score to DXA for fracture prediction in liver transplant patients

Project Nº56
Title: Molecular characterization of Brucella strains

Project Nº 57
Title: Understanding tumor plasticity and non-genetic drug resistance mechanisms of BRAF mutant melanoma 

Project Nº 58 - ASIGNADO
Title:  Enhancing matrix integration and mechanical properties of tissue-engineered cartilage 

Para la realización del trabajo fin de máster en el extranjero el alumno deberá acreditar un nivel avanzado de inglés o el del idioma del país del centro de realización del trabajo fin de master. 

La incorporación del alumno a la institución o empresa nacional o internacional está sujeta a la aceptación por parte del centro que se haya escogido para la realización del TFM.

Asignación de Trabajo Fin de Máster
Los alumnos que no tengan un proyecto ASIGNADO, deben seleccionar dos de los proyectos publicados y comunicar mediante el envío de un email a evines@unav.es, su elección por orden de preferencia. Esta selección y comunicación se hará tras haber formalizado la matrícula del máster. No se podrán por tanto escoger proyectos que figuren como ASIGNADOS.

Por otro lado, los alumnos que tengan el proyecto ASIGNADO, deberán comunicar también cuál es su trabajo fin de máster.

En caso de concurrencia de varios candidatos a un mismo proyecto como primera opción, la adjudicación del proyecto se realizará en base al expediente académico de los candidatos y a su curriculum vitae.

La Comisión Académica del Máster valorará los proyectos seleccionados por los alumnos y se comunicarán las asignaciones por correo electrónico antes del comienzo del curso.

Una vez asignado el Trabajo Fin de Máster y comenzado el curso, no se podrá realizar cambio de proyecto en ningún caso.